The AZOle Resistance MANagement (AZORMAN) study:
The AZORMAN study aims to evaluate if the use of a diagnostic PCR that detects mutations that confer resistance to voriconazole in the CYP51a of A. fumigatus can improve the management and outcome of patients infected with voriconazole resistant A.fumigatus.
Currently UMCU, EMC, UMCG, VUMC, LUMC MUMC and Radboud UMC are involved.
The PosaFlu Study:
Recent studies have shown that patients with very severe influenza are at significant risk of developing an invasive fungal infection with the fungus Aspergillus. The mortality in these patients is very high (51%).
The PosaFlu study is a randomized trial in which the value of posaconazole prophylaxis for the prevention of influenza associated aspergillus infections is investigated in patients admitted to the intensive care with influenza.
The study is enrolling patients in UZ Leuven, AZ Sint Jan in Bruges, UZ Gent in Ghent, Erasmus MC in Rotterdam, Radboud UMC in Nijmegen and UMCG in Groningen.
Retrospective or observational studies:
This prospective multicentre case-control registration study in Dutch and Belgian ICUs will assess the difference in incidence and outcome of invasive pulmonary aspergillosis (IPA) in ICU patients with severe influenza compared with influenza-negative control patients with severe community-acquired pneumonia during the coming three influenza seasons (2017-2020). The study will further assess the differences in clinical characteristics and risk factors between influenza patients with and without invasive aspergillosis.
All consecutive patients aged 18 or older admitted to ICU during the inclusion period with respiratory distress due to influenza positive/negative community acquired pneumonia (CAP) will be included.